摘要：近年来的流行病学调查显示，表皮葡萄球菌已成为医院获得性感染的重要病原菌，主要通过在机体留置医疗设备表面形成生物膜而致病。生物膜作为表皮葡萄球菌感染的主要致病因素，可阻碍抗生素的渗透、增强细菌耐药性及抵御宿主免疫系统的作用，从而导致慢性持续性感染。针对表皮葡萄球菌生物膜致病相关因子进行深入研究，有利于为临床开展相关治疗提供理论支持。

Abstract: Recent epidemiological survey showed that Staphylococcus epidermidis has become an important hospital-acquired infections pathogen, which plants mainly in the surface of the body indwelling medical devices to form pathogenic biofilm. As the major causative factor in Staphylococcus epidermidis infection, the biofilm can hinder the penetration of antibiotics, enhance bacterial resistance, and strengthen the host immune system against host immune system effect, which leading to persistent chronic infection. The depth study of pathogenic factors of Staphylococcus epidermidis biofilm can help provide some theoretical basis for controlling S. epidermidis infections.