摘要：目的  探讨反复体外受精-胚胎移植失败(RIF)患者可能的母体因素发病机制。方法 
对比70例RIF 患者和35例孕前体检者，月经第3天血清卵泡刺激素(FSH)、黄体生成素(LH)、子宫体积、卵巢体积、窦卵泡计数(AFC)和排卵期子宫内膜厚度、分型、优势卵泡数量、子宫螺旋动脉的平均搏动指数(PI)和阻力指数(RI)。 结果  RIF组月经第3天FSH 、LH和FSH/ LH数值均明显上升，子宫体积、卵巢体积和AFC数量均显著下降，差异具有统计学意义 (P＜0.01)；排卵期子宫内膜厚度和优势卵泡数量显著下降，子宫内膜分型A型显著减少，B型和C型明显增加，子宫螺旋动脉PI和RI均明显上升，差异具有统计学意义(P＜0.01)。 结论  卵巢反应性降低和子宫内膜容受性下降与RIF发生有相关性。

Abstract：Objective To explore the possible maternal factors in patients with repeated implantation of in vitro fertilization embryo failure (RIVF). Methods 70 patients of RIVF and 35 pre-pregnancy healthy people were involved in this study. at the serum levels of FSH and LH, uterine and ovarian volume, antral follicle count (AFC) on the third day of menstrual cycle, and endometrial thickness, typing, dominant follicles’ number, pulsatility index(PI) and resistance index (RI) on ovulatory phase in both groups were measured. Results RIF group can The serum levels of FSH, LH and FSH/ LH ratio in RIVF group were obviously increased，while the uterine and ovarian volume and AFC were decreased compared with controls (P＜0.01) . The endometrial thickness and dominant follicles number in RIVF group were significantly decrease (P＜0.01). The endometrial type A reduced markedly, while type B and type C significantly increased. Both PI and RI of uterine spiral artery were increased obviously (P＜0.01). Conclusion The lower ovarian response and descending endometrial receptivity might have positive correlation for the patients with repeated implantation of in vitro fertilization embryo failure .