目的 探讨缺血修饰白蛋白（IMA）、肌钙蛋白（cTnI）、肌红蛋白（MYO）、肌酸激酶同工酶（CK-MB）检测在急性冠状动脉综合征的早期发现中的应用价值。方法 选择100例急性冠状动脉综合征（ACS）患者，在胸痛发作后3小时内检测缺血修饰白蛋白（IMA）、肌钙蛋白（cTnI）、肌红蛋白（MYO），肌酸激酶同工酶（CK-MB），同时选择100例健康查体者为对照组，做相同检测，观察各种心肌标志物的变化。结果 ACS组与对照组的检测结果进行对比，4项指标的差异均具有统计学意义（P＜0.05）。ROC下曲线面积显示，IMA仅次于cTnI，高于MYO和CK-MB。结论 IMA、MYO、cTnI、CK-MB 联合检测在急性冠脉综合征( ACS) 早期诊断中具有重要的临床意义。

Objective To explore the clinical value of Ischemia modified albumin (IMA)，Cardiac troponin I (cTnI)，Myohemoglobin (MYO) and Creatine kinase isozymes (CK-MB) detection in the early diagnosis of acute coronary syndrome (ACS). Methods The serum levels of IMA, cTnI, MYO and CK-MB in 100 patients with acute coronary syndrome (ACS) at 3 hours after chest pain and in 100 healthy cases were detected. Results There were significantly difference on the IMA, cTnI, MYO and CK-MB between ACS group and control group (P<0.05). The areas under ROC curve in ACS group was lower than cTnI, but higher than MYO and CK-MB. Conclusion The combined detection of IMA, cTnI, MYO and CK-MB in acute coronary syndrome have a significant clinical value in the early diagnosis of ACS.