目的 本研究旨在研究家属的焦虑状态是否对脑胶质瘤患者围手术期的应激状态有影响，手术前对家属进行心理干预后，对患者围手术期应激状态的影响。方法 本研究共纳入112例需手术治疗的脑胶质瘤患者，入院后对这些患者随机分为对照组，家属护理干预组，患者护理干预组和家属患者护理干预组，每组28例。对于需要护理干预的家属或患者实行标准，系统化的护理干预。并于患者手术前一天（T1），麻醉诱导前（T2），手术结束（T3），术后24小时（T4）测量患者血压，心率。并且测定血清中皮质醇（Cor）和C反应蛋白（CRP）的浓度。结果 在T1时间点，四组患者的心率、血压、血清Cor和CRP水平均没有显著性差异（P>0.05）。而在T2，T3时间点，家属病人护理干预组的心率、血压、血清Cor和CRP水平均低于其他三组，差异有统计学意义（P <0.01）。而在T4时间点，四组患者的 心率、血压、血清Cor和CRP水平两两之间差异有统计学意义。结论 对家属和病人同时护理干预比仅对患者或仅对家属护理干预更能降低患者围手术期的应激水平。

Objective To investigate the effect of the anxiety of family members on glioma patients the stress state during perioperative period. Methods 112 glioma patients who needed operations were recruited in our study. These patients were divided into controls group, nursing intervention on family members, nursing intervention on patients, nursing intervention on family members and patients group, randomly. Each group included 28 patients. The blood pressure, heart rate, serum levels of cortisol (Cor) and C reactive protein (CRP) of patients were detected on four time points, which were the day before operation (T1), before anesthesia (T2), after surgery (T3) and 24 hours after surgery (T4). Results On the T1 time point, the blood pressure, heart rate, serum levels of Cor and CRP were no significantly different among the four groups (p>0.05). On T2 and T3 time point, the blood pressure, heart rate, serum levels of Cor and CRP in nursing intervention on both family members and patients group were all significantly lower than that of other three groups (p<0.05). On the T4 time point, the blood pressure, heart rate, serum levels of Cor and CRP were all significantly different in the four groups (p<0.05). Conclusion Nursing intervention on both family members and patients could lower the stress levels of giloma patients during perioperative period. It could be better than those nursing interventions on patients or on family members only.