目的　通过口服葡萄糖耐量实验，观察血清C肽、胰岛素释放水平，计算胰岛素敏感指数，探讨肥胖对老年2型糖尿病患者几个指标的影响。方法　选择本院老年2型糖尿病患者136例，根据1999年WHO糖尿病的诊断标准及患者的体重指数分为非肥胖糖尿病组60例和肥胖糖尿病组76例；另选健康检查者92例，分为非肥胖对照组40例和肥胖对照组52例。采用己糖激酶法测定血糖，采用时间分辨荧光免疫法测定C肽和胰岛素。结果　非肥胖糖尿病组与非肥胖对照组，肥胖糖尿病组与肥胖对照组，肥胖对照组与非肥胖对照组，非肥胖糖尿病组与肥胖糖尿病组两两比较，各时间点C肽和胰岛素水平差异均有统计学意义(P<0.05或P<0.01)。肥胖对照组与非肥胖对照组，非肥胖糖尿病组与肥胖糖尿病组两两比较，各时间点血糖水平差异均无统计学意义 (P>0.05)，肥胖者服糖后血糖下降更慢。结论　肥胖影响老年2型糖尿病患者的C肽和胰岛素，为该病的危险因子。

Objective To explore the effect of obesity on serum levels of C-peptide, insulin and glucose in elderly patients with diabetes. Methods 136 cases of elderly patients with diabetes were divided into non-obese diabetic group (60 cases) and obese diabetic group (76 cases) according to the 1999 WHO diagnostic criteria for diabetes and patients with a body mass index. 92 healthy controls were divided into non-obese control group (40 cases), obesity control group (52 cases). The blood glucose was detected by Hexokinase method. The serum levels of insulin and C-peptide were measured by chemiluminescence. Results The serum levels of insulin and C-peptide at all time point had significantly difference between patient groups and healthy control groups (P<0.05). Conclusion The Obesity could significantly affect the serum C-peptide and insulin levels in the elderly patients with type 2 diabetes. It would be a risk factor for this disease.