摘要：目的 研究血清E-选择素与冠状动脉钙化（CAC）发病之间的相关性。方法 将128例汉族CAC患者，分为轻度钙化（MCG）66例，中重度钙化（MSCG）组62例，正常对照（CCNCG）组68例。采集血标本并提取DNA。采用ELISA法检测E-选择素浓度，PCR法进行DNA扩增，检测S128R与G98T多态性基因位点。结果 MSCG组患者血清E-选择素浓度显著高于MCG组和CCNCG组，差异有统计学意义(P<0.01) 结论 血清E-选择素浓度与CAC的发生发展呈正相关。位点S128R在汉族人群中存在遗传变异。

Abstract：Objective To study the influence of the serum E-selection concentration on CAC. Methods 128 Han Chinese patients diagnosed as CAC by coronary angiography examination were selected as the research objects of this study, and were divided into two groups. The two groups included mild calcification group(MCG) and moderately severe calcification group (MSCG). 68 Han nationality persons were selected as coronary artery completely normal control group (CCNCG). Blood specimen was collected and DNA was extracted. Results The serum E-selection level of the patients in MSCG was significantly higher than that in CCNCG. And there was statistically significant difference in these two groups (P < 0.01). The serum E-selection level of the patients in MCG was significantly lower than that in MSCG. And there was statistically significant difference in these two groups (P < 0.01). Conclusion The serum E-selection levels were positively correlated with the incidence and development of CAC. There is genetic variation of S128R in Chinese Han population.