摘要：目的 探讨CCR2、CCL5、CCR5和CCL1的基因多态性与中国汉族儿童结核病易感性的关系。方法：收集353例汉族儿童结核病患者，以同期查体的400 名儿童作为对照，采用病例对照研究，应用高通量MassARRAY技术对于CCR2、CCL5、CCR5和CCL1基因的SNP位点进行基因分型研究。结果 CCR2、CCL5、CCR5和CCL1基因SNP位点的等位基因、基因型以及单体型在结核病组和对照组的分布差异均无统计学意义（P＞0.05）。结论 CCR2、CCL5、CCR5和CCL1的基因多态性与中国汉族儿童结核病易感不存在相关性。

Abstract: Objective To explore the association between polymorphisms of CCR2, CCL5, CCR5 and CCL1 genes and susceptibility of tuberculosis (TB) in Chinese Han Children. Methods 353 TB children and 400 healthy controls were collected in case-control study and MassARRAY was used for genotyping. Results After analysis of alleles, genotypes and haplotypes of single nucleotide polymorphisms (SNPs) of CCR2, CCL5, CCR5 and CCL1 genes, no statistical significance of distribution analysis of SNPs was found in TB group and control group (P＞0.05). Conclusion SNPs of CCR2, CCL5, CCR5 and CCL1 genes were not associated with TB in Chinese Han Children.