摘要：目的 探讨结肠癌患者手术治疗前后血清CEA 、CA72-4 、HCY和 CysC水平的变化及其临床意义。方法 应用放免法、免疫法和胶乳增强免疫法对35例结肠癌患者进行手术治疗前后血清CEA 、CA724 、HCY和 CysC检测，并与35名正常人作比较。结果 结肠癌组在手术治疗前血清CEA 、CA72-4 、HCY和 CysC水平均非常显著地高于正常人组(P<0.01)，手术后6个月未复发的28例中明显下降，接近于正常人组水平，而复发的7例，其数值又回升至手术前水平（P<0.01）。结论 检测结肠癌患者血清CEA 、CA72-4 、HCY和 CysC的变化可作为诊断和疗效观察的指标。

Abstract：Objective To explore the clinical significance of the changes of serum CEA, CA72-4, HCY and Cys C levels both before and after operation in patients with colon cancer. Methods Serum levels of CEA, CA72-4, HCY and Cys C in 31 patients with colon cancer before and after operation as well as in 35 health controls were determined by RIA, immunochemistry and latex–enhanced immunolrubidimetry. Results The serum levels of CEA, CA72-4, HCY and Cys C in the patients before operation were significantly higher than those of the controls (P<0.01). The serum levels of CEA, CA72-4, HCY and Cys C in 28 of postoperative cases without recurrence at 6 months dropped markedly and approached to normal level as in controls. However, the serum levels in 7 patients with recurrence increased and approached to levels as before the surgery (P<0.01). Conclusion The serum levels of CEA, CA72-4, HCY and Cys C might be used as indicators for diagnosis and predicting therapeutic efficacy after operation in patients with colon cancer.