摘要：目的  探讨洛伐他汀促进颌骨骨折愈合过程中对骨形成蛋白-2（BMP-2）的影响。方法  健康家兔24只，于颌骨制造骨折模型，再随机分为给药组和对照组，每组12只，给药组手术次日给予10mg／(kg·d)洛伐他汀灌胃，疗程为28天，对照组给予安慰剂。利用RT-PCR及Western blot检测骨折愈合过程中给药组和对照组骨折后3、7、10、14、21和28天骨痂中BMP-2的表达，同时应用ELISA检测血清中BMP-2的含量。结果  RT-PCR结果显示，给药组BMP-2 基因表达高峰出现在第7天，对照组出现在第14天，且峰值较低。同时Western blot结果显示：术后7～14天骨痂中BMP-2蛋白给药组明显高于对照组，术后21～28天给药组与对照组没有明显差异。血清学检测两组BMP-2升高，在术后14天含量达到高峰，且给药组明显高于对照组(P ＜0.05)。结论  洛伐他汀明显促进颌骨骨折愈合过程中BMP-2的合成与分泌，进而有利于骨折的愈合。

Abstract：Objective To explore the effect of Lovastatin on BMP-2 during fracture healing process of mandibular fracture. Methods The fracture models of mandibular were established in with 24 rabbits. The rabbits were randomly and equally divided into medication group and control group, in which the rabbits were lavaged with Lovastatin of 10 mg/kg per day and placebo for 4 weeks since the next day after fracture. The expression of BMP-2 protein in bony callins were determined by PT-PCR and Western blot method on days 3，7，10，14，21，and 28 of fracture．The concentration of BMP-2 in serum was analyzed by ELISA. Results On days of 7 of fracture, BMP-2 gene expression was reach at the peak in medication group. However, the gene expression of BMP-2 in control group was delayed (on days of 14) in comparison with medication group. The results of HE stain showed that the positive cells of BMP-2 in experiment groups were higher than that in control group on days 7 and 14 (P <0.05), but on day 28 there was no different compared to control group (P>0.05). BMP-2 in serum were detected after fracture, and high expression of BMP-2 was detected on day 14 after fracture in medication group, which was higher than that in control group (P <0.05)．Conclusion Lovastatin could promote the synthesis and secretion of BMP-2 during fracture healing, which can accelerate healing process of mandubular fracture.