目的 探讨癌胚抗原（CEA)、糖类抗原19-9(CA19-9)、CYFRA21-1和铁蛋白（Fer)在鉴别良恶性胸腔积液中的临床意义。方法 应用化学发光法对53例恶性胸腔积液和41例良性胸腔积液中的CEA、CA19-9、CYFRA21-1和Fer进行含 量检测,并对测定的结果进行比较。结果 恶性胸腔积液组的四项指标高于良性组,差异具有统计学意义（P <0.01)。 四项肿瘤标志物诊断恶性胸腔积液的阳性率分别为:CEA 75. 47% , CYFRA21-1 77.35%, CA19-9 66. 03%, Fer 52.8%。 四项标志物联合检测阳性率可达90.1%。结论 四项肿瘤标志物联合检测对良恶性胸腔积液的鉴别诊断有重要意义。

Objective To explore the clinical significance of combined detection of CEA, CYFRA21-1, CA19-9 and Fer in the differential diagnosis of benign pleural effusion and malignant ones. Methods The serum levels of CEA, CYFRA21-1, CA19-9 and Fer in 53 patients with malignant pleural effusion and 41 patients with benign pleural effusion were detected by chemiluminescence detection technology. Results The serum levels of four items in malignant pleural effusion group were significantly higher than those of the benign group (P < 0. 01). The positive rates of CEA, CYFRA21-1, CA19-9 and Fer in the diagnosis of malignant pleural effusion were 75. 47% , 77.35% , 66. 03% and 52. 8% respectively. The positive rate of combined detection of four items was 90. 1% . Conclusion The combined detection of CEA, CYFRA21-1 , CA19-9 and Fer present higher contents in malignant pleural fluid which play a role in differential diagnosis between malignant and benign pleural effusion.